Evidence map›Paper›PMID 40531379›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2025

Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men.

Qudus A Ojikutu, Jeann L Sabino-Carvalho, Katherine Latham, Marcos Rocha, Joao D Mattos, Monique O Campos, Daniel E Mansur, Lauro C Vianna, Antonio C L Nóbrega, Igor A Fernandes

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qudus A OjikutuHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.
Jeann L Sabino-CarvalhoDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8482-5135
Katherine LathamHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.
Marcos RochaAugust Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0390-3139
Joao D MattosLaboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-7377-9348
Monique O CamposIndiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-9526-0937
Daniel E MansurLaboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-3441-9910
Lauro C ViannaNeuroV̇ASQ̇, Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasília, Brasília, Federal District, Brazil.ORCID http://orcid.org/0000-0002-5747-0295
Antonio C L NóbregaLaboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-3830-2886
Igor A FernandesHuman Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA. igorfernandes@purdue.edu.ORCID http://orcid.org/0000-0003-3873-2656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxia is a common feature of arterial hypertension that does not consistently elevate blood pressure (BP), but triggers exaggerated increases in muscle sympathetic nerve activity (MSNA) and may disturb sympathetic transduction and baroreflex sensitivity in hypertensive individuals. Elevated resting MSNA, enhanced sympathetic transduction, and reduced baroreflex sensitivity are all associated with increased blood pressure variability (BPV), a marker of target organ damage independent of absolute BP levels. We hypothesized that hypoxia would elicit greater BPV in hypertensive individuals compared to normotensive controls

methodsNine young- to middle-aged men with untreated stage 1-2 hypertension (HT) and normotensive controls (NT) were exposed to normoxia (21% O

conclusionsIn conclusion, IH similarly exacerbates BPV and disrupts sympathetic transduction and baroreflex function in normotensive and untreated hypertensive men, despite greater MSNA reactivity in the hypertensive group.

Indexed as

BaroreflexBlood PressureHypertensionHypoxiaSympathetic Nervous SystemAdultCarbon DioxideCase-Control StudiesHumansMaleMiddle AgedOxygen SaturationCarbon DioxideArterial baroreflexHypertensionSympathetic nervous system

Identifiers

PMID40531379
PMCPMC12664846

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.