Evidence map›Paper›PMID 40531376›Full record

ReviewJournal of gastroenterology2025

Gastrointestinal health and nutritional strategies in autism spectrum disorder.

Yuqi Wu, Oscar Wing Ho Wong, Sizhe Chen, Siew Chien Ng, Qi Su, Francis Ka Leung Chan

Abstract readReview
In one paragraph

Review in Journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuqi Wu *Microbiota I-Center (MagIC), 10/F, Building 17W, 17 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China.
Oscar Wing Ho Wong *Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sizhe ChenMicrobiota I-Center (MagIC), 10/F, Building 17W, 17 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China.
Siew Chien NgMicrobiota I-Center (MagIC), 10/F, Building 17W, 17 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China.
Qi SuMicrobiota I-Center (MagIC), 10/F, Building 17W, 17 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China. qisu@cuhk.edu.hk.
Francis Ka Leung ChanMicrobiota I-Center (MagIC), 10/F, Building 17W, 17 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China. fklchan@cuhk.edu.hk.

Funding

Hong Kong PhD Fellowship Scheme (HKPFS) of the Research Grants Council of Hong Kong PF22-77807New Cornerstone Science Foundation NCI202346Research Grants Council-Research Impact Fund R4030-22
6 · The paper itself

Abstract

Beyond the hallmark social and sensory difficulties in autism spectrum disorder (ASD), the comorbid gastrointestinal (GI) conditions and their potential link to the severity of core symptoms require clinical attention. Although evidence indicates that autistic children face a greater risk of GI disorders and require more intensive nutritional management compared to neurotypical peers, standard guidelines for managing GI symptoms in this population remain lacking. This review seeks to pinpoint critical considerations for the implementation of nutrition-based strategies aimed at addressing GI dysfunction in individuals with ASD. By emphasizing clinical translation and the mechanistic understanding of these strategies, it highlights the importance of restoring gut homeostasis as a pathway to improve functional independence and overall well-being. Furthermore, we outline priorities for clinical research aimed at developing evidence-based nutritional recommendations to support GI health in autistic individuals, emphasizing personalized and population-specific needs.

Indexed as

Autism Spectrum DisorderDietGastrointestinal DiseasesAlgorithmsAnalgesics, OpioidBrain-Gut AxisDietary SupplementsGastrointestinal MicrobiomeHumansPrebioticsProbioticsAnalgesics, OpioidPrebioticsAutismClinical practiceGastrointestinal symptomsNutritional managementPrecise nutrition

Identifiers

PMID40531376
PMCPMC12289859

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.