Evidence map›Paper›PMID 40531369›Full record

ReviewDrug delivery and translational research2025

Advances in constructing biocompatible nanocarriers.

Xuehui Duan, Xinlei Chu, Yan Du, Yixuan Tang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Multifunctional rGO/YRSC advances · 2026
    Article
  5. Article
  6. Quo Vadis translational neuroscience?Translational neuroscience · 2026
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xuehui DuanSchool of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Xinlei ChuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Yan DuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Yixuan TangSchool of Pharmaceutical Sciences & Institute of Materia Medica, Medical Science and Technology Innovation Center, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. tangyixuan@sdfmu.edu.cn.ORCID 0000-0003-2755-8269

Funding

Shandong Province Medical and Health Science and Technology Project 202413020649Special funds for Taishan Scholars Project tsqnz20221156
6 · The paper itself

Abstract

The design of effective drug nanocarriers requires the prevention of adverse biological interactions such as immune activation and cytotoxicity, making superior biocompatibility a critical determinant for clinical success. While existing reviews predominantly focus on the therapeutic applications of nanomedicines, systematic analyses of biocompatibility optimization strategies remain scarce. To address this gap, we present a review of three primary approaches for constructing biocompatible nanocarriers: (1) inert-material-based frameworks, (2) polymer surface engineering techniques, and (3) biomimetic functionalization methodologies. By evaluating the structural designs and biological mechanisms of commonly employed materials, we elucidated how these strategies leverage inherent material properties and biological interaction principles to regulate biocompatibility. Furthermore, we analyzed the advantages and limitations of each approach, offering guidance for selecting the optimal biocompatibility enhancement methods. This work not only synthesizes current advancements in biocompatible nanocarrier development but also provides actionable insights to advance nanomedicine research and clinical translation.

Indexed as

Biocompatible MaterialsDrug CarriersNanoparticlesAnimalsHumansNanomedicinePolymersBiocompatible MaterialsDrug CarriersPolymersBiocompatibilityBiomimetic strategiesInert carriersNanocarriersPolymer modification

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.