Evidence map›Paper›PMID 40531333›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2025

Au(I)-based compounds inhibit nsp14/nsp10 and nsp13 (helicase) to exert anti-SARS-CoV-2 properties.

Jingxin Chen, Xueying Wei, Chun-Lung Chan, Kaiming Tang, Shuofeng Yuan, Hongyan Li, Hongzhe Sun

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingxin Chen *Department of Chemistry and HKU-CAS Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Xueying Wei *Department of Chemistry and HKU-CAS Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Chun-Lung ChanDepartment of Chemistry and HKU-CAS Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Kaiming TangDepartment of Microbiology and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Shuofeng YuanDepartment of Microbiology and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Hongyan LiDepartment of Chemistry and HKU-CAS Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Hongzhe SunDepartment of Chemistry and HKU-CAS Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. hsun@hku.hk.

Funding

Research Grants Council, University Grants Committee 17318322University Research Committee, University of Hong Kong Norman & Cecilia Yip Foundation
6 · The paper itself

Abstract

Au(I) compounds have long been associated with medicine for the treatment of various diseases, especially auranofin has been used for the treatment of rheumatoid arthritis. In addition, Au(I) based compounds also exhibit anti-cancer, anti-bacteria properties. The recent prevalence of the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has aroused attention to investigate the antiviral potential of Au(I) compounds. Herein we demonstrate the pan-anti-SARS-CoV-2 activity of Au(I) metallodrugs in mammalian cells. We synthesized a panel of Au(I)-based compounds and found that these compounds could effectively inhibit the exoribonuclease and methyltransferase activities of SARS-CoV-2 nsp14/nsp10 complex, and the ATPase and DNA unwinding activities of SARS-CoV-2 nsp13 (helicase). Mechanistic studies reveal that Au(I) can not only displace the critical Zn(II) ions from nsp14/nsp10 complex and nsp13 but also changes the secondary and quaternary structure of nsp14 and perturbate the DNA unwinding of nsp13 by disrupting the ATP binding. This study illustrates a multi-target feature Au(I) compounds/drug agents for the viruses, highlighting their potential as pan-anti-SARS-CoV-2 (or relevant viruses) agents.

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentDNA HelicasesExoribonucleasesGoldOrganogold CompoundsSARS-CoV-2Viral Nonstructural ProteinsCOVID-19HumansMethyltransferasesRNA HelicasesViral Regulatory and Accessory ProteinsAntiviral AgentsDNA HelicasesExoribonucleasesGoldMethyltransferasesNsp13 protein, SARS-CoVNSP14 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2Organogold CompoundsRNA HelicasesViral Nonstructural ProteinsViral Regulatory and Accessory ProteinsAntiviralGoldHelicaseMetallodrugnsp14SARS-CoV-2

Identifiers

PMID40531333
PMCPMC12316777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.