ArticleAMB Express2025
Anticancer, antimicrobial and molecular docking analysis of newly synthesized iodoquinazoline derivatives.
Article in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
The 4-anilinoquinazoline sulfonamide derivatives in medicinal chemistry are well-known antitumor backbones via different mechanisms. Herein, we reported the synthesis of five new 2,4-disubstituted-6-iodoquinazoline derivatives coded compounds 3a-e. The respective compounds were examined for their antiproliferative, antimicrobial, and carbonic anhydrase XII (CAXII) inhibitory activity against four cancerous cell lines. Compound 3c was proven to be the most effective as an anticancer. It stopped the growth of the four used tumor cell lines at concentrations ranging from 4.0 to 8.0 µM as compared to the reference doxorubicin (2.3-3.25 µM). Compound 3b, was able to stop the proliferation of the tumor cell lines with IC
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