ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age-Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEarly age-onset colorectal cancer (EAO-CRC) strikes during the reproductive years, yet pregnancies before and after diagnosis have not been thoroughly studied. Our objective was to comprehensively examine: (i) the relationship between gravida and EAO-CRC and (ii) the relationship between EAO-CRC and births after cancer diagnosis.
methodsWe conducted a case-control and a cohort study using administrative health data from British Columbia, Canada, of females diagnosed with EAO-CRC from 2005 to 2017 and age- and sex-matched cancer-free controls. Multivariable logistic regression models were used to evaluate: (i) the association between gravida assessed over the 5-year prodrome period before cancer diagnosis and EAO-CRC and (ii) the association between EAO-CRC and births assessed over a 5-year period following cancer diagnosis.
resultsThe study sample consisted of 865 females (age at EAO-CRC diagnosis 42.5 ± 6.1 years) with EAO-CRC and 8,291 controls (42.4 ± 6.3 years). Females with a gravida of ≥2 in the 5-year prodrome period had 1.82 times the odds of EAO-CRC compared with those with gravida of 0 (OR, 1.82; 95% confidence interval, 1.19-2.78). After cancer diagnosis, females with EAO-CRC had significantly lower odds of giving birth within five years (OR, 0.23; 95% confidence interval, 0.15-0.37). Older age, lower income, rural residence, and greater healthcare utilization were associated with lower odds of post-diagnosis births.
conclusionsOur study highlights the complex relationship between reproductive health and EAO-CRC. IMPACT: Findings indicate a need for comprehensive psychosocial support addressing family planning for female patients with EAO-CRC.
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