ArticleJournal of proteome research2025
The Effect of Preanalytical Conditions on Blood-Based Inflammation Biomarkers.
Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Blood-based inflammation biomarkers have potential for diagnostic, prognostic, and predictive testing, but preanalytical processing conditions can affect biomarker levels. We investigated how needle-to-freezer time, centrifugation timing, and tube types influence inflammation biomarkers. Twenty subjects donated 21 different blood samples in collection tubes, including plasma and serum types. Ninety-two biomarkers from each sample were analyzed using the Olink Target 96 Inflammation panel. We compared biomarker concentrations across different preanalytical variables to a reference standard tube. Intraclass, Pearson, and Spearman's correlation coefficients were calculated. We also assessed the impact of these conditions on age-related associations with biomarkers. Across the preprocessing protocol/blood matrix combinations, 38%-83%, 50%-87%, and 47%-79% of proteins showed good to excellent correlations in intraclass, Pearson, and Spearman analyses, respectively. Eighteen proteins differed by >0.5 NPX units between test and reference protocols. Among 30 comparisons of age-related biomarker associations showing
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