Evidence map›Paper›PMID 40531177›Full record

ArticleMicrobial genomics2025

An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in

Dylan Adlard, Lavania Joseph, Hermione Webster, Ailva O'Reilly, Jeffrey Knaggs, Tim E A Peto, Derrick W Crook, Shaheed V Omar, Philip W Fowler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Structural and functional analysis of theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dylan AdlardNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Lavania JosephCentre for Tuberculosis, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Johannesburg, South Africa.
Hermione WebsterNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Ailva O'ReillyNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Jeffrey KnaggsNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Tim E A PetoNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Derrick W CrookNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.
Shaheed V OmarCentre for Tuberculosis, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Johannesburg, South Africa.
Philip W FowlerNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bedaquiline (BDQ) has only been approved for use for just over a decade and is a key drug for treating multidrug-resistant tuberculosis; however, rising levels of resistance threaten to reduce its effectiveness. Catalogues of mutations associated with resistance to BDQ are key to detecting resistance genetically for either diagnosis or surveillance. At present, building catalogues requires considerable expert knowledge, often requires the use of complex grading rules and is an irreproducible process. We developed an automated method, catomatic, that associates genetic variants with resistance (or susceptibility) using a two-tailed binomial test with a stated background rate and applied it to a dataset of 11,867

Indexed as

Antitubercular AgentsDiarylquinolinesDrug Resistance, BacterialMycobacterium tuberculosisWhole Genome SequencingAlgorithmsGenome, BacterialHumansMicrobial Sensitivity TestsMutationTuberculosis, Multidrug-ResistantAntitubercular AgentsbedaquilineDiarylquinolinesbedaquilineresistancetuberculosiswhole-genome sequencing

Identifiers

PMID40531177
PMCPMC12177157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.