ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Magnetoelectric Nanoparticles Enable Modulation of Cortical Networks by Low-Intensity Static Magnetic Fields In Vitro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modulation of slow and fast oscillations by direct current stimulation in the cerebral cortex in vitro.The Journal of physiology · 2026Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Understanding how brain stimulation interacts with the brain's internal dynamics is crucial for developing effective neuromodulation protocols. Here we explore the effects of exogenous alternating current (AC) fields across various amplitudes and frequencies on cortical slices expressing spontaneous slow oscillations. Cortical network entrainment occurs within an Arnold tongue-like region centered at the endogenous frequency. However, slightly detuned periodic stimulation of higher frequency leads to a desynchronized regime, revealing a novel approach for disrupting pathological synchronicity. The introduction of an additional direct current (DC) offset expands the modulatory ranges, facilitating the achievement of either entrainment or desynchronization, depending on the DC offset's polarity. The experimental observations are quantitatively reproduced by a computational model of spiking neurons, suggesting that the interaction between nonlinear oscillators can predict the network's response to AC fields. Besides an improved understanding of cortical dynamics and its interaction with exogenous electric fields, a robust protocol with potential clinical applications in pathological conditions is presented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.