Evidence map›Paper›PMID 40530950›Full record

ArticleJournal of surgical oncology2025

Decreasing Complications After Ivor-Lewis Esophagectomy: Is a Totally Minimally Invasive Approach the Solution?

Parit T Mavani, Caitlin Sok, Pranay S Ajay, Yichun Cao, Alicia M Bonanno, Kenneth Cardona, Felix G Fernandez, Seth D Force, Onkar V Khullar, Maria C Russell and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Parit T MavaniDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-3968-1205
Caitlin SokDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Pranay S AjayDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-9292-8345
Yichun CaoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health of Emory University, Atlanta, Georgia, USA.
Alicia M BonannoDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Kenneth CardonaDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-8200-3269
Felix G FernandezDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Seth D ForceDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Onkar V KhullarDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Maria C RussellDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1584-6992
Charles A StaleyDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Mihir M ShahDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-4665-5534
David A KoobyDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8694-0455
Manu S SanchetiDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Emory Clinical Oncology Career Development Award K12 ProgramK12CA237806 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, KAVITA MADHAV, RAMALINGAM, SURESH S · 2019 to 2023
$2.2M
Financial support was provided by the National Cancer Institute of the National Institutes of Health (NIH/NCI) under award number K12 CA237806 from the Emory K12 Clinical Oncology Training Program (awarded to MMS), the Georgia Clinical and Translational Science Awards (CTSA) ULI TR002378 (awarded to MMS) and NIH/NCI P30CA138292 (awarded to Biostatistics Shared Resource). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Additional support is in part by the Contardi Research Fellowship. The acknowledged parties had no role in study design, data collection, analysis and interpretation of data, manuscript writing and decision to submit the manuscript for publication.NCATS NIH HHS UL1 TR002378NCI NIH HHS K12 CA237806NCI NIH HHS P30 CA138292
6 · The paper itself

Abstract

backgroundDespite improvements over time, Ivor Lewis Esophagectomy (ILE), a potentially curative surgical option for patients with invasive esophageal cancer, carries high morbidity and mortality. We analyzed postoperative outcomes in patients undergoing ILE at our institution, comparing open (OE), hybrid (HE), and totally minimally invasive (TMIE) approaches.

methodsWe reviewed the records of patients who underwent elective ILE for benign or malignant pathology at our institution (2018-2022). Patients who underwent transhiatal or McKeown esophagectomy, as well as those undergoing emergent procedures, were excluded. Factors associated with major postoperative complications (Clavien-Dindo Grade ≥ 3) were assessed using multivariable analysis (MVA).

resultsOf 260 patients, 135 met the inclusion criteria: 40 (29.6%) underwent OE, 50 (37.0%) underwent HE, and 45 (33.3%) underwent TMIE. Median length of stay was shorter for patients undergoing TMIE compared to OE and HE (9 vs. 12 and 13 days, p < 0.001). A higher major postoperative complication rate was noted in patients undergoing OE and HE compared to TMIE (32.5% and 36% vs. 13.3%) (p = 0.03). This result persisted on MVA (OE: aOR 3.4, p = 0.04; HE: aOR 5.5, p = 0.002; reference:TMIE).

conclusionA totally minimally invasive approach to Ivor-Lewis Esophagectomy is associated with lower major postoperative complications and shortened length of stay at our institution. Prospective evaluations in the United States population are warranted to optimize and standardize surgical approaches.

Indexed as

Esophageal NeoplasmsEsophagectomyMinimally Invasive Surgical ProceduresPostoperative ComplicationsAdultAgedAged, 80 and overElective Surgical ProceduresFemaleHumansLength of StayMaleMiddle AgedNeoplasm InvasivenessRetrospective StudiesTreatment OutcomeIvor‐Lewis esophagectomyminimally invasive approachoperative approachpostoperative complication

Identifiers

PMID40530950
PMCPMC12354262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.