Evidence map›Paper›PMID 40530948›Full record

ArticleOrganic letters2025

Cascade Grignard Addition: Propargyl Claisen Rearrangement for the Stereoselective Synthesis of α-Allene Quaternary Centers in Cyclohexanones.

Estefania Armendariz-Gonzalez, Adi Saputra, Edward W Mureka, Cale M Locicero, Gabrielle L Womble, Gloria Tan, Abigail A Watson, Frank R Fronczek, Rendy Kartika

Abstract read
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In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Estefania Armendariz-Gonzalez232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Adi Saputra232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Edward W Mureka232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Cale M Locicero232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Gabrielle L Womble232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Gloria Tan232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Abigail A Watson232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Frank R Fronczek232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.ORCID 0000-0001-5544-2779
Rendy Kartika232 Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.ORCID 0000-0002-2042-2812

Funding

New Synthetic Chemistries Enabled by Oxyallyl and 2-Aminoallyl CationsR01GM127649 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KARTIKA, RENDY GREGORY · 2018 to 2022
$1.4M
NIGMS NIH HHS R01 GM127649
6 · The paper itself

Abstract

We report a new method for the enantio- and diastereoselective synthesis of α-allene quaternary centers in fully substituted cyclohexanones at the α-positions. This reaction involves asymmetric 1,2-carbonyl addition to 2-

Identifiers

PMID40530948
PMCPMC12305655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.