Evidence map›Paper›PMID 40530937›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2025

Retention in HIV Care Still Matters: A Longitudinal Multisite Analysis.

Emma Sophia Kay, John R Bassler, Melanie C Goebel, Lindsay Browne, Katerina Christopoulos, Heidi M Crane, Barbara Gripshover, Kenneth H Mayer, Richard D Moore, Michael J Mugavero and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emma Sophia KaySchool of Nursing, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-8425-9196
John R BasslerCenter for AIDS Research, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Melanie C GoebelBaylor College of Medicine, Houston, TX.
Lindsay BrowneSchool of Medicine, University of North Carolina, Chapel Hill, NC.
Katerina ChristopoulosSchool of Medicine, University of California San Francisco, San Francisco, CA.
Heidi M CraneSchool of Medicine, University of Washington, Seattle, WA.
Barbara GripshoverUniversity Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Kenneth H MayerThe Fenway Institute, Boston, MA.
Richard D MooreSchool of Medicine, Johns Hopkins University, Baltimore, MD ; and.
Michael J MugaveroHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Thomas P GiordanoBaylor College of Medicine, Houston, TX.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2021 to 2025
$8.3M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI161943NIAID NIH HHS R24 AI067039NIH HHS P30AI050410NIH HHS P30AI161943NIMH NIH HHS R25 MH083620NIMH NIH HHS R25MH083620-14
6 · The paper itself

Abstract

introductionRetention in care has recently been de-emphasized as a key national HIV health metric, and its relevance in the era of more effective antiretroviral therapy regimens remains unclear. We assessed the relationship between retention in care and sustained viral suppression (SVS) over a 2-year period for newly established and previously established people with HIV (PWH).

methodsWe analyzed data from 7 Center for AIDS Research Network of Integrated Clinical Systems (CNICS) sites using modified Poisson regression with generalized estimating equations. PWH were categorized into 2 cohorts: (1) newly established: had initial CNICS visit in 2017 and antiretroviral therapy (ART)-naïve at initial CNICS visit and (2) previously established: had initial CNICS visit before January 1, 2017, or PWH who were not ART-naïve at initial CNICS visit in 2017. Retention was measured using both missed and kept visit-based metrics. The primary outcome was SVS over 2 years, defined as all viral load measurements ≤200 copies/mL.

resultsAmong 11,994 patients, 11,573 were previously established in HIV care and 421 were newly established and ART-naive. A higher proportion of previously vs. newly established patients were retained in care and achieved SVS. In both cohorts, when controlling for age, sex, race, and risk factor of HIV acquisition, both retention measures were observed to be a predictor of SVS.

conclusionsRetention in care remains a clinically valuable metric for all PWH. Healthcare providers should emphasize consistent care engagement, and national HIV/AIDS strategies should reincorporate retention as a key indicator for improving HIV health outcomes.

Indexed as

Anti-HIV AgentsHIV InfectionsRetention in CareAdultFemaleHumansLongitudinal StudiesMaleMiddle AgedViral LoadAnti-HIV Agentsadherenceengagement in careHIVHIV policyretention in careviral load

Identifiers

PMID40530937
PMCPMC13011880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.