Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents.

Mengfan He, Christina M Thomson, Dawn Thompson, Vytautus Kuodis, Terry K Smith, Sergio Dall'Angelo, David O'Hagan

Abstract read

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A Supramolecular Ferroelectric With Two Sublattices and Polarization Dependent Conductivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengfan HeSchool of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9S, UK.

Christina M ThomsonInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Dawn ThompsonInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.ORCID https://orcid.org/0000-0003-0948-9458

Vytautus KuodisSchool of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9S, UK.

Terry K SmithSchool of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9S, UK.

Sergio Dall'AngeloInstitute of Medical Sciences and John Mallard Scottish PET Centre, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.ORCID https://orcid.org/0000-0001-9377-0474

David O'HaganSchool of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9S, UK.ORCID https://orcid.org/0000-0002-0510-5552

Funding

China Scholarship Council

6 · The paper itself

Abstract

A series of all-cis-ring-fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4-fluorophenylalanine and pentafluoroarylphenylalanine is introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G-protein coupled formylpeptide receptor, FPR2. Selected all-cis-ring cyclohexylalanines of this class are also incorporated into a keto-piperazine molecular scaffold to generate sp

Indexed as

OligopeptidesPiperazinesReceptors, Formyl PeptideTrypanocidal AgentsTrypanosoma brucei bruceiHalogenationHumansStructure-Activity RelationshipOligopeptidesPiperazinesReceptors, Formyl PeptideTrypanocidal Agentsanti‐trypanosomesbioactivesorgano‐fluorinesW‐peptides

Identifiers

PMID40530886

DOI10.1002/cbic.202500384

PMCPMC12631002

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.