Evidence map›Paper›PMID 40530878›Full record

ArticlemBio2025

Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict

Víctor R Vázquez Marrero, Jessica Doerner, Kimberly A Wodzanowski, Jenna Zhang, Allyson Lu, Frankie D Boyer, Isabel Vargas, Suzana Hossain, Karly B Kammann, Madison V Dresler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Human non-canonical inflammasomes activate CASP3 to limit intracellularbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Víctor R Vázquez MarreroDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5134-3244
Jessica DoernerDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kimberly A WodzanowskiDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8948-6788
Jenna ZhangDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Allyson LuDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Frankie D BoyerDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Isabel VargasDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Suzana HossainDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Karly B KammannDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Madison V DreslerDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6647-6392
Sunny ShinDepartment of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5214-9577

Funding

University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1M
UPenn Post Baccalaureate Research Education Program.R25GM071745 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BHOJ, ELIZABETH JOYCE, KESSLER, DANIEL S · 2005 to 2024
$6.4M
Innate immune-mediated control of pulmonary Legionella pneumophila infectionR01AI118861 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2025
$4.6M
ST Research Education Program to Increase Diversity in Health Related ResearchR25HL084665 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DELISSER, HORACE M, SHIN, SUNNY · 2006 to 2024
$2.2M
Training in Microbial Pathogenesis and GenomicsT32AI141393 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D, ZHU, JUN · 2019 to 2023
$1.3M
American Heart AssociationBurroughs Wellcome FundNational Science Foundation Graduate Research Fellowship Program DGE-1845298NHLBI NIH HHS R25 HL084665NIAID NIH HHS R01 AI118861NIAID NIH HHS T32 AI141393NIGMS NIH HHS K12 GM081259NIGMS NIH HHS R25 GM071745NIH HHS AI141393-03NIH HHS K12GM081259NIH HHS R01AI118861, R21AI12178NIH HHS R25GM071745-19NIH HHS R25HL084665
6 · The paper itself

Abstract

The innate immune system relies on pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs) and guard proteins to monitor pathogen disruption of host cell processes. How different immune cell types engage PRRs and guard proteins to respond to infection is poorly understood. Here, we show that macrophages and dendritic cells (DCs) distinctly respond to bacterial virulence activities. In macrophages, the bacterial pathogen

Indexed as

ApoptosisDendritic CellsLegionella pneumophilaLegionnaires' DiseasePyroptosisAnimalsBacterial ProteinsCaspases, InitiatorHost-Pathogen InteractionsImmunity, InnateInflammasomesMacrophagesMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinType IV Secretion SystemsBacterial ProteinsCaspases, InitiatorInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinType IV Secretion Systemsapoptosiscaspase-11dendritic cellsguard immunityinnate immunityLegionella pneumophilapyroptosis

Identifiers

PMID40530878
PMCPMC12239575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.