Evidence map›Paper›PMID 40530823›Full record

ArticleBiomarkers in medicine2025

Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing.

Seyed Reza Mirhafez, Zeinab Shateri Amiri, Atena Mansouri, Saeed Mohammadian Haftcheshmeh, Peyman Habibi, Fatemeh Abdollahi, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seyed Reza MirhafezNoncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Zeinab Shateri AmiriDepartment of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Atena MansouriCellular & Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Saeed Mohammadian HaftcheshmehHealthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Peyman HabibiHealthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Fatemeh AbdollahiHealthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Stephen L AtkinResearch Department, Royal College of Surgeons in Ireland Bahrain, Adliya, Bahrain.
Tannaz JamialahmadiPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-8656-1444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine PAB levels as a predictor of all-cause and cause-specific mortality in adult and elderly subjects.

methodsThe data from 386 subjects who had died during the study were age- and sex-matched to 386 subjects that remained alive, and PAB levels were compared. PAB was evaluated using a mixed enzymatic/chemical method involving simultaneous oxidation and reduction of the chromogen 3,3',5,5'-tetramethylbenzidine by prooxidants and antioxidants, respectively, leading to measurable colorimetric changes.

resultsPAB levels showed an increased risk of mortality (OR: 1.018; 95%CI: 1.010-1.025,

conclusionsIncreasing PAB levels were significantly associated with increasing all-cause mortality suggesting that PAB measurement may have utility in indicating disease severity and have differential prognostic value in acute and chronic clinical scenarios.

Indexed as

AgingAntioxidantsCOVID-19OxidantsReactive Oxygen SpeciesAdultAgedAged, 80 and overBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedSARS-CoV-2AntioxidantsBiomarkersOxidantsReactive Oxygen SpeciesantioxidantdeathinflammationOxidative stressreactive oxygen species

Identifiers

PMID40530823
PMCPMC12233873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.