ArticleMicrobiology spectrum2025
Comparison of classic and novel human astrovirus MLB and VA seroprevalence in HIV and non-HIV cohorts in South China demonstrates high seroreactivity to classic human astrovirus, which is associated with HIV infection.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human astroviruses (HAstVs), including classic and novel clades (MLB, VA), are enteric pathogens with increasing clinical significance, particularly in immunocompromised populations. This cross-sectional study investigated HAstV seroprevalence and antibody response profiles in 197 individuals (101 HIV-positive and 96 HIV-negative) from Guangdong Province, South China. Recombinant HAstV1, MLB2, and VA1 spike proteins were expressed in IMPORTANCE: Human astroviruses (HAstVs) are increasingly implicated in severe systemic and neurological infections, yet their seroepidemiology in immunocompromised populations remains poorly characterized. This study provides critical insights into the divergent immune responses to classic and novel HAstV clades among people living with HIV (PLWH) in southern China. We demonstrate that PLWH displayed heightened antibody responses to classic HAstV1 but reduced reactivity to MLB2, suggesting HIV-driven immune dysregulation may selectively boost infection with classic HAstV strains. These findings highlight the need for targeted surveillance and improved diagnostics for HAstV infections in high-risk populations.
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