ArticleNucleic acids research2025
Landscape of A-I RNA editing in mouse, pig, macaque, and human brains.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Multi-Tissue Genetic Regulation of RNA Editing in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
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Authors and funding
15 authors.
Funding
Abstract
Adenosine-to-inosine (A-I) RNA editing is one of the most abundant post-transcriptional RNA modification processes. However, the roles of A-I RNA editing in the evolution and functions of primate brains are underexplored. Here, we perform whole-genome and whole-transcriptome sequencing of 39 anatomically defined brain regions of adult Macaca fascicularis and identify 2 782 079 A-I editing sites, including 2009 recoding sites enriched in genes related to neurotransmission functions. Most of macaque brain A-I editing sites are detected in the cerebral cortex, cerebellum, and amygdala. The brain A-I editing activity is associated with the estimated proportion of neurons to some extent. Comparison of A-I editing in mouse, pig, macaque, and human brains reveals that primates exhibit higher editing levels, specifically enriched in genes encoding neurotransmitter receptors. We identify 478 598 conserved brain editing sites between human and macaque brains, mostly found in the cerebral cortex and enriched in genes related to the cytoskeletal system and ubiquitin-dependent protein degradation pathway. Our study sheds light on the importance of post-transcriptional A-I RNA editing in the evolution and function of nervous systems.
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Registered trials
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