ArticleCancer2025
An examination of factors associated with disparities in clinical trial eligibility guided by the Socioecological Model.
Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Drivers of Research Participation Among Racially and Ethnically Underrepresented Women: Insights from Semi-Structured Interviews.Journal of racial and ethnic health disparities · 2026Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPatients from diverse demographic groups remain underrepresented in cancer clinical trials (CCTs) because of various factors, including disparities in eligibility. In the current study, the authors investigated associations between demographic characteristics and factors associated with CCT eligibility and enrollment using real-world data.
methodsA cross-sectional analysis was conducted among 113,030 adult patients with cancer who were treated at Moffitt Cancer Center between 2011 and 2021. Eligibility criteria from 100 CCTs were manually abstracted and conceptually mapped to variables in the Moffitt Cancer Analytics Platform. Other factors potentially affecting patient eligibility or enrollment in CCTs were identified following the Socioecological Model and were compared across patient groups by age, sex, race, and ethnicity.
resultsThe most frequent eligibility criteria in the abstracted CCTs included laboratory results associated with liver function (89%) and bone marrow function (88%). Thirty-nine percent of the protocols required genetic testing. Black/African American patients experienced a higher prevalence of diabetes (Δ = 3.2%), human immunodeficiency virus infection (Δ = 1.4%), and abnormal laboratory results compared with White patients. Hispanic patients experienced a higher prevalence of human immunodeficiency virus infection (Δ = 0.2%) and a history of organ transplantation (Δ = 0.2%) compared with non-Hispanic patients. Compared with younger patients, older adults had a higher prevalence of nononcologic conditions. Female, Black, and/or Hispanic patients were more likely to experience barriers to care, including childcare and transportation, and to live in more socially deprived areas compared with male, White, or non-Hispanic patients.
conclusionsRestrictive CCT eligibility criteria and social determinants of health may pose structural barriers that disproportionately affect patient diversity. Investigators should leverage real-world data to design appropriate trial eligibility criteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.