Evidence map›Paper›PMID 40530606›Full record

ArticleJournal of the American Geriatrics Society2025

Relationship of Visual Impairment and Poor Mobility With Mortality.

Atalie C Thompson, Joseph Rigdon, Michael E Miller, Stephen B Kritchevsky

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Relationship of Visual Impairment and Poor Mobility With Mortality.Journal of the American Geriatrics Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Atalie C ThompsonDepartment of Surgical Ophthalmology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.
Joseph RigdonDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.
Michael E MillerDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.
Stephen B KritchevskyDivision of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Deep learning to quantify glaucomatous damage on fundus photographs for teleophthalmologyK23EY030897 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMPSON, ATALIE C · 2020 to 2024
$968k
Doris Duke Charitable Foundation 2023-0232NCATS NIH HHS UM1 TR004929NCATS NIH HHS UM1TR004929NEI NIH HHS K23 EY030897NEI NIH HHS K23EY030897NIA NIH HHS N01-AG-6-2101NIA NIH HHS N01-AG-6-2103NIA NIH HHS N01-AG-6-2106NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG028050NIA NIH HHS R01-AG028050NINR NIH HHS R01 NR012459NINR NIH HHS R01-NR012459
6 · The paper itself

Abstract

backgroundOlder adults with visual impairment (VI) have a greater risk of mortality, but the reasons are poorly understood. We have shown that older adults with VI are more likely to have poor mobility performance on the short physical performance battery (SPPB). In this analysis, we examined whether VI predicted mortality over 10 years and if this was related to poor baseline mobility (SPPB < 9).

methodsWe analyzed 2457 older adults (mean age 75.6 (±2.8) years, 38.5% black, 51.9% female) who completed vision testing at the year 3 visit in the Health, Aging and Body Composition study. Cox proportional hazards models for mortality were right-censored at 10 years and adjusted for demographic and clinical comorbidities. VI (visual acuity < 20/40 or log contrast sensitivity < 1.55 or stereoacuity > 85) and SPPB < 9 were tested as main predictors and their interaction was tested.

resultsIn separate multivariable models, VI (HR 1.511, 95% CI [1.335-1.709], p < 0.0001) and SPPB < 9 (HR 1.442, 95% CI [1.210-1.717], p < 0.0001) each predicted mortality. When including both poor mobility and vision variables as main effects, both poor mobility and impaired vision remained significant predictors of mortality in all models (all p < 0.001). When adding poor mobility (as a main effect and interaction with VI) and using unimpaired vision and mobility as the reference, those with only VI (HR 1.467, 95% CI [1.287-1.672], p < 0.0001) or only poor mobility (HR 1.380, 95% CI [0.963-1.979], p = 0.0792) had similar HRs, while those with both VI and poor mobility had an increased mortality risk (HR 2.035, 95% CI [1.643-2.522], p < 0.0001), but the interaction was not significant (p = 0.981).

conclusionsOlder adults with both VI and poor mobility are at an additive increased risk of mortality. Future interventions may want to target older adults with both VI and poor mobility to improve survival.

Indexed as

Mobility LimitationMortalityVision DisordersAgedAged, 80 and overFemaleGeriatric AssessmentHumansMaleProportional Hazards ModelsRisk FactorsVisual Acuitymobilitymortalityvision

Identifiers

PMID40530606
PMCPMC12354233

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.