Evidence map›Paper›PMID 40530508›Full record

ArticleJournal of the American Heart Association2025

Incremental Prognostic Value of Hippocampal Metabolic Activity for Sudden Cardiac Death in Patients With Heart Failure With Reduced Ejection Fraction.

Zhiyong Shi, Mingkai Yun, Binbin Nie, Yujie Bai, Yaqi Zheng, Enjun Zhu, Yuetao Wang, Marcus Hacker, Yongqiang Lai, Baoci Shan and 3 more

Abstract read
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In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhiyong ShiDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital Capital Medical University Beijing China.ORCID 0000-0003-1310-4821
Mingkai YunDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital Capital Medical University Beijing China.ORCID 0000-0002-3107-1472
Binbin NieDivision of Nuclear Technology and Applications Institute of High Energy Physics, Chinese Academy of Sciences Beijing China.
Yujie BaiDepartment of Nuclear Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou China.ORCID 0000-0002-5139-5378
Yaqi ZhengDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital Capital Medical University Beijing China.
Enjun ZhuDepartment of Cardiac Surgery, Beijing Anzhen Hospital Capital Medical University Beijing China.
Yuetao WangDepartment of Nuclear Medicine The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China.ORCID 0000-0003-2859-8625
Marcus HackerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy Medical University of Vienna Vienna Austria.ORCID 0000-0002-4222-4083
Yongqiang LaiDepartment of Cardiac Surgery, Beijing Anzhen Hospital Capital Medical University Beijing China.
Baoci ShanDivision of Nuclear Technology and Applications Institute of High Energy Physics, Chinese Academy of Sciences Beijing China.
Sijin LiDepartment of Nuclear Medicine First Hospital of Shanxi Medical University Taiyuan Shanxi China.ORCID 0000-0002-2010-3459
Xiaoli ZhangDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital Capital Medical University Beijing China.ORCID 0000-0002-0770-5594
Xiang LiDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy Medical University of Vienna Vienna Austria.ORCID 0000-0002-0016-6233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHippocampal injury is linked to cognitive impairment and cardiac events in patients with heart failure with reduced ejection fraction. However, the predictive value of hippocampal metabolic activity (HMA) for sudden cardiac death (SCD) and the underlying mechanisms remain unclear. This study aimed to evaluate the independent and incremental predictive value of HMA over myocardial scar for SCD-related events in patients with heart failure with reduced ejection fraction and to explore the potential mechanism.

methodsThis prospective study included 270 patients with heart failure with reduced ejection fraction undergoing gated single-photon emission computed tomography and brain/cardiac

resultsOverall, 34 (12.6%; median follow-up, 4.3 years) patients experienced SCD-related events. Functional myocardial scarring and HMA were strongly associated with SCD-related events (all

conclusionsFunctional myocardial scarring and HMA had strong independent prognostic value in the risk stratification of SCD-related events in patients with heart failure with reduced ejection fraction. Additionally, HMA had incremental prognostic value based on myocardial scarring. HMA impairment may induce SCD-related events, partly mediated by corrected QT interval.

Indexed as

Death, Sudden, CardiacHeart FailureHippocampusStroke VolumeVentricular Function, LeftAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsFluorodeoxyglucose F1818F‐FDG PET/CTheart failurehippocampusmyocardial scarringsudden cardiac death

Identifiers

PMID40530508
PMCPMC12449996

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.