Evidence map›Paper›PMID 40530496›Full record

ArticleEuropean journal of neurology2025

Long-Term Detection of Subclinical Atrial Fibrillation in Cryptogenic Stroke Patients With Insertable Cardiac Monitors.

Leonardo Pantoni, Francesco Mele, Francesca Pescini, Martina Rafanelli, Cecilia Zivelonghi, Luca Tomasi, Giacomo Mugnai, Caterina Tomaselli, Alfredo Petrone, Alessandro Adami and 11 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Leonardo PantoniNeuroscience Research Center, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.ORCID 0000-0001-7357-8530
Francesco MeleNeurology Unit, Ospedale Sacco, Milan, Italy.
Francesca PesciniStroke Unit, Department of Neurosciences and Sense Organs, Careggi University Hospital, Florence, Italy.ORCID 0000-0003-4565-5601
Martina RafanelliSyncope Unit, Department of Geriatrics and Intensive Care, Careggi University Hospital, Florence, Italy.
Cecilia ZivelonghiNeurology and Stroke Unit, Neurosciences Department, University Hospital of Verona, Verona, Italy.
Luca TomasiDivision of Cardiology, Cardio-Thoracic Department School of Medicine, University Hospital of Verona, Verona, Italy.
Giacomo MugnaiDivision of Cardiology, Cardio-Thoracic Department School of Medicine, University Hospital of Verona, Verona, Italy.
Caterina TomaselliCardiology & ICU Unit - Civile SS. Annunziata Hospital, Cosenza, Italy.
Alfredo PetroneNeurology Unit - Civile SS. Annunziata Hospital, Cosenza, Italy.
Alessandro AdamiStroke Center, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Italy.
Giulio MolonCardiology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Italy.
Pasquale CreaCardiology Unit, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", University of Messina, Messina, Italy.
Paolino La SpinaStroke Unit, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", University of Messina, Messina, Italy.
Giuseppe CarulloCardiology and ICU - Azienda Sanitaria Provinciale Vibo Valentia, "G. Jazzolino" Hospital, Vibo Valentia, Italy.
Franco GalatiNeurology Unit - Azienda Sanitaria Provinciale Vibo Valentia, "G. Jazzolino" Hospital, Vibo Valentia, Italy.
Sebastiano LumeraCardiology and ICU Unit, P.O Guzzardi, ASP Ragusa, Vittoria, Italy.
Antonello GiordanoNeurology and Stroke Unit, P.O Guzzardi, ASP Ragusa, Vittoria, Italy.
Giulia MatteucciSyncope Unit, Department of Geriatrics and Intensive Care, Careggi University Hospital, Florence, Italy.
Giuseppe ScopellitiNeurology Unit, Ospedale Sacco, Milan, Italy.
Giovanni ForleoCardiology Unit, Luigi Sacco Hospital, Milan, Italy.
Andrea UngarSyncope Unit, Department of Geriatrics and Intensive Care, Careggi University Hospital, Florence, Italy.

Funding

Medtronic Italy
6 · The paper itself

Abstract

backgroundLong-term continuous monitoring with insertable cardiac monitor (ICM) is recommended after cryptogenic stroke (CS) by current guidelines to detect subclinical atrial fibrillation (SCAF). However, long-term real-world data on ICM-SCAF detection and ensuing therapy are limited. The aim of this study was to assess long-term SCAF detection rate in a large cohort of CS patients with ICM.

methodsData of consecutive CS patients receiving ICM from September 2016 to February 2024 in 20 Italian centers were collected. Patients were followed with remote and outpatient follow-up according to clinical practice. SCAF was diagnosed if a device-detected SCAF daily burden ≥ 5 min was confirmed by a cardiologist.

resultsSeven hundred and eighty-nine CS patients with ICM (mean age 69.3 ± 11.7 years, 40.3% females, 79.0% CHA

conclusionsThis multicenter real-world project confirmed that ICM allows the detection of SCAF in one third of CS patients 48 months after the stroke, leading to anticoagulation in most of them.

Indexed as

Atrial FibrillationElectrocardiography, AmbulatoryIschemic StrokeStrokeAgedAged, 80 and overFemaleHumansMaleMiddle Agedatrial fibrillationcardiac remote monitoringcryptogenic strokeinsertable cardiac monitorstroke

Identifiers

PMID40530496
PMCPMC12174957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.