Evidence map›Paper›PMID 40530427›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Simulation of cerebrospinal fluid (CSF)-venous fistula embolization in a swine model: A technical video.

Esref Alperen Bayraktar, Jonathan Cortese, Julien Ognard, Gerard El Hajj, Cem Bilgin, Ramanathan Kadirvel, David F Kallmes, Waleed Brinjikji

Abstract read
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esref Alperen BayraktarDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8245-2689
Jonathan CorteseDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Julien OgnardDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4495-7464
Gerard El HajjDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8896-8280
Cem BilginDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6243-9495
Ramanathan KadirvelDepartment of Neurological Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6786-9953
David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8495-0040
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
Drug Eluting Embolization Coils for Improved Treatment of Intracranial AneurysmsR44NS107111 · NINDS · ANCURE, LLC · PI BETTINGER, CHRISTOPHER JOHN, KADIRVEL, RAMANATHAN · 2018 to 2020
$1.2M
Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysmsR43NS110114 · NINDS · ENDOMIMETICS, LLC · PI HWANG, PATRICK, KADIRVEL, RAMANATHAN · 2019 to 2019
$563k
Rapidly healing flow diverters using magnetic cell targeting for intracranial aneurysm treatmentR21NS128199 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI KADIRVEL, RAMANATHAN, TEFFT, BRANDON J · 2022 to 2023
$447k
NINDS NIH HHS R01 NS076491NINDS NIH HHS R21 NS128199NINDS NIH HHS R43 NS110114NINDS NIH HHS R44 NS107111
6 · The paper itself

Abstract

Cerebrospinal fluid venous fistulas (CSFVF) can lead to spontaneous intracranial hypotension, causing debilitating symptoms in patients. The transvenous embolization technique has been developed to occlude leakage sites via an endovascular approach. However, the spinal venous anatomy remains relatively unfamiliar to many neurointerventionalists. This technical video presents a swine model designed to train physicians in navigating the spinal venous system, performing embolization injections, observing their spread, and testing new embolization systems for treating CSFVF. Although there are slight anatomical differences, the spinal venous system in swine closely resembles that of humans, including its navigability and employing liquid embolic agents. We successfully embolized multilevel spinal vasculature that can potentially drain into a fistula formation, without any complications.

Indexed as

animal modelCerebrospinal fluid-venous fistulaCSF leakendovascular embolizationspontaneous intracranial hypotension

Identifiers

PMID40530427
PMCPMC12210133

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.