Evidence map›Paper›PMID 40530409›Full record

ArticleResuscitation plus2025

Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial: a

Mattias Bohm, Kristofer Årestedt, Susann Ullén, Niklas Nielsen, Josef Dankiewicz, Hans Friberg, Erik Blennow Nordström, Alain Cariou, Janus Christian Jakobsen, Anders Morten Grejs and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mattias BohmBrain Injury After Cardiac Arrest Research Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Kristofer ÅrestedtFaculty of Health and Life Sciences, Linnaeus University, Kalmar, Sweden.
Susann UllénClinical Studies Sweden - Forum South, Skåne University Hospital, Lund, Sweden.
Niklas NielsenDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Josef DankiewiczDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Hans FribergDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Erik Blennow NordströmBrain Injury After Cardiac Arrest Research Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Alain CariouMedical Intensive Care Unit, Cochin University Hospital, AP-HP Centre Université Paris Cité, Paris, France.
Janus Christian JakobsenCopenhagen Trial Unit, Centre for Clinical Intervention Research, Capital Region of Denmark, Denmark.
Anders Morten GrejsDepartment of Intensive Care Medicine, Aarhus University Hospital, Denmark.
Matthias HaenggiInstitute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.
Naomi E HammondCritical Care Program, The George Institute for Global Health, UNSW Sydney, Barangaroo, Australia.
Katarina HeimburgBrain Injury After Cardiac Arrest Research Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Thomas R KeebleEssex Cardiothoracic Centre, Nethermayne, Basildon, Essex, UK.
Christoph LeithnerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology and Experimental Neurology, Augustenburger Platz 1, 13353 Berlin, Germany.
Christian RylanderAnesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Johan UndénAnaesthesiology and Intensive Care Medicine, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Matt P WiseAdult Critical Care, University Hospital of Wales, Cardiff, UK.
Tobias CronbergBrain Injury After Cardiac Arrest Research Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Gisela LiljaBrain Injury After Cardiac Arrest Research Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Our aim was to investigate the psychometric properties of the health assessment instrument EQ-5D-5L in OHCA survivors. Methods: We included survivors from the Targeted Hypothermia versus Targeted Normothermia after OHCA (TTM2) trial, who completed EQ-5D-5L at 6 months. Confirmatory factor analysis was used to evaluate the hypothesised unidimensional latent structure of EQ level sum score (EQ LSS), summarizing scores across Results: 783 of 939 (84%) eligible survivors were included. Confirmatory factor analysis showed good model fit and strong factor loadings for all dimensions (0.61-0.90). We observed a significant but negligible effect of age on Mobility (β = 0.29, p < 0.001, ΔR Conclusion: The psychometric properties of EQ LSS support its use to measure health status in OHCA research. The strong association between health and functional dependency indicate robust and comparable construct validity for EQ LSS, EQ value, and EQ VAS in this sample.

Indexed as

Cross-sectional studiesHealth statusHeart arrestPatient reported outcome measuresPsychometricsValidation study

Identifiers

PMID40530409
PMCPMC12173684

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.