ReviewFrontiers in systems neuroscience2025
Recent advances on the mechanism of acupuncture in the treatment of subjective tinnitus.
Review in Frontiers in systems neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Research Progress on Pathogenesis, Modern Interventions and Neuromodulatory Mechanisms of Acupuncture for Tinnitus.International journal of general medicine · 2026Review
- From bidirectional pathophysiology to integrative therapeutics: current status and future perspectives of acupuncture for tinnitus-insomnia comorbidity.Frontiers in psychiatry · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To review and organize the research results on the mechanism of action of acupuncture in the treatment of subjective tinnitus over the past 30 years. This will provide a reference basis for the clinical acupuncture treatment of subjective tinnitus. Methods: Computer searches of PubMed, China National Knowledge Infrastructure (CNKI), and China Science and Technology Journal Database (CCD) were conducted to collect and organize literature on the research on the mechanism of action of acupuncture in the treatment of subjective tinnitus. The searches were limited to the period from January 1, 1995 to July 31, 2024. The literature was then summarized and analyzed in terms of the blood circulation of the inner ear, immuno-inflammation, and neural cells to elaborate on the potential mechanism of action of acupuncture. The objective of this study was to describe the potential mechanism of action of acupuncture. The final results yielded 36 research papers related to subjective tinnitus and the mechanism of action of acupuncture. The identified mechanisms are as follows: the enhancement of local microcirculation in the inner ear by regulating the blood supply of the vertebrobasilar artery may improve the inner ear's blood supply obstacle. Additionally, the reduction of immuno-inflammatory factors in the inner ear may reduce the toxicity of the cochlea's hair cells and protect them. The modulation of 5-hydroxytryptamine receptors in the cochlear nucleus may serve to protect spiral ganglion neurons from damage. Additionally, the modulation of the thalamus and the functional reorganization of the auditory cortex and synaptic network may contribute to the achievement of therapeutic effects. Conclusion: While acupuncture has demonstrated clinical efficacy in the treatment of subjective tinnitus, the underlying mechanism of action remains poorly understood. In the future, there is a need to accelerate the application of modern advanced technology and multidisciplinary cross-fertilization, as well as to conduct in-depth and systematic investigations into the mechanisms of acupuncture effects. This will provide an objective basis for clinical treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.