Evidence map›Paper›PMID 40530331›Full record

ArticleFrontiers in cell and developmental biology2025

Perillaldehyde synergizes with ferroptosis inducers to promote ferroptotic cell death in gastric cancer.

Rui Wang, Jin-Feng Cui, Jing Lv, Jia-Lin Song, Yang-Yang Lu, Xiao-Juan Huang, Zhong-Kun Lin, Si-Yi Zhang, Sha-Sha Wang, Wen-Sheng Qiu

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui Wang *Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jin-Feng Cui *Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jing LvDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jia-Lin SongDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yang-Yang LuDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xiao-Juan HuangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhong-Kun LinDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Si-Yi ZhangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Sha-Sha WangDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Wen-Sheng QiuDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: As a traditional medicine and food homologous plant, Perilla frutescens is widely cultivated in China, Japan, and Korea. According to the Methods: We performed Results: In this study, PAH was proven to inhibit the growth of gastric cancer both Discussion: Our research suggests a potential therapeutic strategy in which PAH could be used to synergize with ferroptosis inducers for treating gastric cancer.

Indexed as

ferroptosisgastric cancernatural productsoxidative stressperillaldehyde

Identifiers

PMID40530331
PMCPMC12170665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.