ArticleCureus2025
Refractory Diarrhea After Dor Fundoplication: The Long-Term Impact of Proton Pump Inhibitor Therapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent diarrhea following hiatal hernia repair is a rare but noteworthy postoperative complication. In this case, we present a 62-year-old female with a longstanding history of gastroesophageal reflux disease (GERD) responsive to proton pump inhibitors (PPIs). After undergoing robotic-assisted hiatal hernia repair with partial fundoplication, the patient discontinued PPI therapy and subsequently developed chronic diarrhea. Extensive testing, including stool cultures, returned negative, and antidiarrheal medications provided minimal relief. Interestingly, reintroduction of PPI therapy resulted in a complete resolution of symptoms within days. This case suggests a possible correlation between cessation of long-term PPI use and gastrointestinal dysfunction, with chronic diarrhea manifesting as a withdrawal-like effect. Further investigation into the role of PPI discontinuation on gut microbiota and its clinical outcomes is necessary to understand this phenomenon better.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.