ArticleTranslational cancer research2025
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- GJB2, a novel transcription target of HSF4, confers tumorigenic and metastatic phenotypes and sustains mitochondrial homeostasis in lung adenocarcinoma via the PI3K/AKT pathway.Cell adhesion & migration · 2026Article
- SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway.The Kaohsiung journal of medical sciences · 2026Article
- Translational insights and clinical challenges of targeting cancer stem cells.Signal transduction and targeted therapy · 2026Review
- Sex-related differences in gene expression in early-stage bladder cancer revealed by whole-transcriptome sequencing.BMC cancer · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung adenocarcinoma (LUAD) is a prevalent malignancy characterized by low survival rates and poor prognosis. Gap junction beta-2 protein ( Methods: Differentially expressed genes (DEGs) related to CSC properties were analyzed using the Gene Expression Omnibus (GEO) and Gene Expression Profiling Interactive Analysis 2 (GEPIA 2) databases. Protein expression was assessed via western blotting, and gene expression was quantitative real-time polymerase chain reaction (qRT-PCR) in LUAD cell lines. Loss-of-function experiments were performed to evaluate the impact of Results: GJB2 was associated with the CSC properties in LUAD, with its expression upregulated in LUAD cell lines. GJB2 downregulation impaired proliferation, reduced migration, and induced apoptosis in A549 and H1299 cells. Mechanistically, Conclusions:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.