ArticleActa endocrinologica (Bucharest, Romania : 2005)
A STEPWISE APPROACH TO LOCALIZATION STUDIES IN PRIMARY HYPERPARATHYROIDISM.
Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical outcomes of parathyroidectomy in primary hyperparathyroidism: a 10-year single-center experience with 115 procedures.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Primary hyperparathyroidism (PHP) is a prevalent endocrine disorder requiring surgical treatment. The rise of minimally invasive parathyroidectomy as the favored surgical approach emphasizes the significance of localization studies. This study aims to explore clinical and laboratory profiles of PHP patients and evaluate the efficacy of diverse localization methods in a substantial patient cohort. Methods: We analyzed clinical features, biochemical parameters, and imaging outcomes for localization, as well as postoperative histopathological findings in 327 diagnosed PHP patients who underwent surgery. Initial localization methods, which included ultrasonography (US), US-guided Parathormone (PTH) washout analysis, and 99mTechnetium-Sestamibi/123Iodine Scintigraphy (MIBI-SPECT/CT), were applied to all patients. Advanced techniques like Four-Dimensional Computed Tomography (4D-CT) and 18F-Fluorocholine Positron Emission Tomography (18F-FCH PET/CT) were used for cases where initial methods failed and/or for secondary intervention. Results: Minimally invasive surgery accounted for 74% (n=241) of cases. Histopathological analysis revealed single adenoma in 94.5% (n=309) patients, hyperplasia in 5.2% (n=17), and cancer in 0.3% (n=1). Adenoma volume showed a significant positive correlation with serum calcium and parathyroid hormone (PTH) levels (p<0.001). 82 and 26 cases required 4D-CT and 18F-FCH PET/CT respectively, for localization. Positive predictive values (PPV) for imaging modalities were: US (84.56%), US-guided PTH-washout analysis (87.30%), MIBI-SPECT/CT (92.1%), 4D-CT (81.94%), and 18F-FCH PET/CT (95.83%). Conclusion: Serum calcium and PTH levels estimate adenoma size. Initial localization studies (i.e.US, PTH washout and, MIBI-SPECT/CT) effectively localized most adenomas. 4D-CT showed notable efficacy, and 18F-FCH PET/CT had the highest PPV for adenoma localization when the initial studies failed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.