ArticleFrontiers in psychiatry2025
Association between atherogenic index of plasma and depression in individuals with different glucose metabolism status.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Higher psychological frailty index is associated with incident cardiometabolic diseases in Chinese adults aged 45 years and older.Scientific reports · 2026Article
- Remnant Cholesterol Inflammatory Index and Its Association With All-Cause Mortality Among General Population and Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From Two Nationwide Studies.Clinical cardiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The atherogenic index of plasma (AIP) has been implicated in various disease processes, yet its relationship with depression, particularly in the context of differing glucose metabolism status, remains underexplored. This study aimed to investigate the association between AIP and depression in middle-aged and older adults with varying glucose metabolism profiles. Methods: Data were derived from the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011 and 2018, encompassing 7,723 participants aged 45 years and above. Depression was defined using a cutoff score of ≥12 on the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10). The primary outcome of interest was incident depression. Logistic regression and restricted cubic spline (RCS) models were applied to assess the relationship between baseline AIP levels and depression risk across distinct glucose metabolism categories. Results: Elevated AIP was strongly associated with increased odds of depression. In fully adjusted models, a graded relationship was observed, with higher quartiles of AIP corresponding to greater depression risk. Participants in the highest AIP quartile (Q4) had significantly increased odds of depression (odds ratio [OR]: 3.36, 95% confidence interval [CI]: 2.67-4.24, P < 0.001) compared to those in the lowest quartile (Q1). Furthermore, RCS analyses revealed a significant positive association between AIP and incident depression among individuals with prediabetes mellitus (Pre-DM) and diabetes mellitus (DM) (P < 0.001), whereas no such association was found in participants with normal glucose regulation (NGR) (P = 0.086). These findings suggest that glucose metabolism status modifies the relationship between AIP and depression risk. Conclusion: Higher baseline AIP levels are significantly associated with an increased risk of depression in middle-aged and older adults, with distinct effects modulated by glucose metabolism status. These results highlight the potential utility of AIP as a biomarker for depression risk and suggest that metabolic health should be considered in the development of targeted strategies for depression prevention and intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.