Evidence map›Paper›PMID 40530043›Full record

ArticleMaterials today. Bio2025

Highly printable and multifunctional cell-laden collagen-based bioinks for precise DLP bioprinting and rapid diabetic wound regeneration.

Caihong Fu, Guangyu Liu, Yirui Fan, Lang Xiao, Wenhua Li, Xinyu Tian, Jianxi Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caihong FuState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Guangyu LiuState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Yirui FanState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Lang XiaoState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Wenhua LiState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Xinyu TianState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Jianxi XiaoState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital light processing (DLP) bioprinting has revolutionized tissue engineering by offering unprecedented speed and precision. However, its full biomedical potential is hindered by the scarcity of cell-laden bioinks that combine excellent printability with superior bioactivity. In this study, we introduce a novel cell-laden collagen-based bioink optimized for precise DLP bioprinting and diabetic wound regeneration. This bioink integrates methacrylated collagen (CMA) with dihydromyricetin (DHM) and selected additives, achieving a combination of low concentration, high printability, and superior cell bioactivity, along with antioxidant and anti-inflammatory effects. By employing a multi-crosslinking strategy that integrates free radical polymerization, Michael addition, Schiff base formation, and hydrogen bonding, the bioink achieves an ultra-fast gelation speed (375 % increase), a 161 % increase in stiffness, a 231 % improvement in mechanical resilience, and a 208 % enhancement in anti-biodegradation. These properties allow for the fabrication of intricate, cell-laden constructs with micron-scale precision, high cell viability, minimal swelling, and enhanced structural stability. The CMA-DHM system synergistically enhances 3D cell proliferation, mitigates oxidative stress, and modulates macrophage polarization, significantly outperforming conventional CMA hydrogels. Leveraging these properties, we developed biomimetic skin substitutes encapsulating human dermal fibroblasts (HDFs), which effectively facilitate diabetic wound progression through critical healing phases. These skin substitutes provide potent antioxidant and anti-inflammatory effects, accelerate re-epithelialization and collagen deposition, and enhance angiogenesis, thereby preventing chronic wound formation and facilitating efficient tissue regeneration. This study establishes a versatile, scalable DLP bioprinting platform, offering a rapid and effective solution for chronic wound treatment, representing a significant advancement in regenerative medicine.

Indexed as

3D bioprintingCollagen hydrogelsDiabetic wound healingSkin substitutesWound dressings

Identifiers

PMID40530043
PMCPMC12171822

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.