ArticleFrontiers in veterinary science2025
Curcumin and selenium synergistically mitigate oxidative stress in white-feathered broilers.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Baicalin Modulates Hepatic Lipid Metabolism and Improves Intestinal Health in White-Feathered Broilers.Biology · 2026Article
- Curcumin modulates targeted gut bacterial populations and NF-κB/NRF2 immune-redox responses in Eimeria-challenged broilers fed soybean or canola oil.Scientific reports · 2026Article
- A novel traditional Chinese medicine compound alleviates broiler ascites syndrome by modulating the IL-6/STAT3/FOXO3a signaling pathway.Poultry science · 2026Article
- Effects of Short-Term Feeding of Resveratrol on Growth Performance, Meat Quality, Antioxidant Capacity, Serum Biochemical Parameters and Intestinal Health in Yellow-Feathered Broilers Under Dexamethasone-Induced Oxidative Stress.Antioxidants (Basel, Switzerland) · 2025Article
- Curcumin and Selenium Synergistically Alleviate Oxidative Stress in IPEC-J2 Cells and ICR Mice.Biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oxidative stress is closely linked to various diseases in chickens, representing an urgent concern that needs to be addressed in the poultry industry. Curcumin (CUR) and selenium (Se) are both recognized for their great antioxidant effects, however, the combination use of them in broilers has not been reported. This study aims to demonstrate the synergistic antioxidant effects of CUR and Se Methods: The experiments were conducted on the DF-1 cell line and 400 healthy male White-feathered Broilers, day old, weighing 43.89 ± 0.70 g. Hydrogen peroxide (H₂O₂) and dexamethasone (Dex) were used to conduct oxidative stress model. Results: The results demonstrated that CUR and Se synergistically enhanced the antioxidant capacity of DF-1 cells, with a combination index (CI) less than 1; next, CUR and Se increased the total antioxidant capacity and superoxide dismutase (SOD) activity, decreased lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels in broiler liver and heart tissues, alleviated Dex-induced liver and heart injury and liver cell apoptosis in broilers; moreover, the protein expression of IGF-1, PI3K-p110β, phosphorylated AKT and phosphorylated mTOR in liver and heart tissues were increased after the combination treatment. Discussion: In conclusion, CUR and Se alleviate oxidative stress in White-feathered Broilers synergistically, and the synergistic antioxidant effects are related to IGF-1/PI3K/AKT/mTOR pathway.
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