Evidence map›Paper›PMID 40530008›Full record

ReviewFrontiers in oncology2025

The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies.

Rui Zhao, Jiaju Tian, Jing Peng, Ruiting Ma, Songbo Fu

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui ZhaoThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Jiaju TianThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Jing PengThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Ruiting MaThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Songbo FuThe First Clinical Medical College, Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid cancer represents the most prevalent malignant neoplasm within the endocrine system, exhibiting a steadily increasing global incidence. Non-coding RNAs (ncRNAs) have emerged as a pivotal focus in thyroid cancer research, demonstrating significant involvement in tumor progression through epigenetic regulation. Contemporary studies reveal widespread dysregulation of ncRNA expression profiles in thyroid malignancies, where differentially expressed ncRNAs exert either tumor-suppressive or oncogenic functions by modulating epithelial-mesenchymal transition (EMT) mechanisms. This review synthesizes current knowledge on EMT-related ncRNA mechanisms driving thyroid carcinogenesis and evaluates their diagnostic and therapeutic potential. By elucidating these molecular interactions, we aim to catalyze discovery of novel ncRNA-mediated pathways, advance targeted treatment strategies, and ultimately enhance clinical outcomes for thyroid cancer patients.

Indexed as

circRNAsdiagnostic biomarkersepithelial-mesenchymal transitionlncRNAsmiRNAsnon-coding RNAsthyroid cancer

Identifiers

PMID40530008
PMCPMC12171307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.