ArticleJournal of inflammation research2025
Fibrinogen-to-Albumin Ratio as a Novel Predictor of Intracerebral Hemorrhage in Maintenance Hemodialysis Patients.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Intracerebral hemorrhage (ICH) is a life-threatening complication in patients undergoing maintenance hemodialysis (MHD), yet reliable biomarkers for early risk stratification remain scarce. The fibrinogen-to-albumin ratio (FAR), a composite inflammatory and nutritional marker, may offer predictive value for ICH in this high-risk population. Methods: This retrospective study analyzed a total of 536 MHD patients (ICH group: n=207; non-ICH group: n=329) from June 2019 to June 2024. FAR was calculated based on laboratory parameters. Multivariate Logistic regression analysis was used to identify independent risk factors for ICH, and ROC curve analysis and restricted cubic spline (RCS) modeling were used to assess the predictive performance of FAR for cerebral hemorrhage in maintenance hemodialysis patients. Finally, the DeLong test was used to compare the differences in area under curve (AUC). Results: Logistic regression analysis revealed that FAR ([OR] 1.07, 95% [CI] 1.03-1.10, Conclusion: FAR may predict the occurrence of ICH in MHD patients. This study explores the application value of FAR in predicting ICH risk in MHD patients, providing a new biomarker for early identification of high-risk patients in clinical practice.
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