ReviewFrontiers in genetics2025
Genetic profiling and precision skin care: a review.
Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Molecular Targets in Modern Cosmetic Science.Molecules (Basel, Switzerland) · 2026Review
- [Chronic skin damage from UV radiation].Dermatologie (Heidelberg, Germany) · 2026Review
- Antarctic soil microbiomes as a reservoir for cosmetic bioactives: continental-scale diversity and predicted functions.Genes & genomics · 2026Article
- From skin aging biomarkers to precision esthetic longevity: a translational diagnostic framework.Frontiers in medicine · 2026Article
- Skin microbiome and cutaneous aging mechanisms and clinical implications.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes such as elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) play pivotal roles in processes like elasticity, hydration, and pigmentation, directly impacting both intrinsic and extrinsic aging pathways. Understanding these genetic mechanisms is crucial for advancing personalized anti-aging products and therapies, particularly given the significant variability among individuals and ethnic groups. This review explores the current state of knowledge regarding the genetic determinants of skin aging, highlighting recent discoveries and proposing functional pathways for targeted interventions. Future directions are discussed to highlight the transformative potential of these innovations in clinical and aesthetic dermatology. While genetic factors may account for up to 60% of skin aging variability in specific populations, this figure should be interpreted with caution. It primarily reflects heritability under controlled conditions and does not negate the significant influence of modifiable lifestyle and environmental factors on skin and overall aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.