Evidence map›Paper›PMID 40529762›Full record

ArticleJournal of thoracic disease2025

Impact of perineural invasion in thoracic esophageal squamous cell carcinoma-a retrospective study with long-term follow-up outcomes.

Jicheng Xiong, Simiao Lu, Shuoming Liang, Hainan Chen, Ziwei Wang, Hao Meng, Yehan Zhou, Qifeng Wang, Yan Miao, Qin Xie and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jicheng Xiong *Department of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0009-0001-9784-3033
Simiao Lu *Department of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shuoming LiangDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Hainan ChenDepartment of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Ziwei WangDepartment of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Hao MengDepartment of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yehan ZhouDepartment of Pathology, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Qifeng WangDepartment of Radiation Oncology, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Yan MiaoDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Qin XieDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Guangyuan LiuDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Kangning WangDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Lin PengDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Qiang FangDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Wenguang XiaoDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Yongtao HanDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.
Xuefeng LengDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The prognostic role of perineural invasion (PNI) in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to assess the prognostic effects of PNI in resectable ESCC patients. Methods: We retrospectively examined the medical records of patients who underwent esophagectomy from January 2010 to December 2017 at Sichuan Cancer Hospital. Factors associated with PNI and the impact of PNI on prognosis and overall survival (OS) were analyzed. We also performed survive analysis associated with OS and disease-free survival (DFS). Results: The median follow-up period in this study was 36.7 months. PNI was present in 18.0% (404/2,247) of ESCC patients. PNI-positive was correlated with a shorter OS than PNI-negative (median OS: 31 Conclusions: PNI is a potential independent prognostic factor for ESCC patients. Further study is needed to determine whether postoperative adjuvant therapy is necessary for thoracic ESCC patients who have achieved R0 resection and PNI-positive.

Indexed as

disease-free survival (DFS)Esophageal squamous cell carcinoma (ESCC)overall survival (OS)perineural invasion (PNI)

Identifiers

PMID40529762
PMCPMC12170199

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