Evidence map›Paper›PMID 40529545›Full record

ArticleFrontiers in human neuroscience2025

Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy.

Marlon L Wong, Lisa M McTeague, Gabriel Gonzalez, Juan P Gonzalez, Jessica L Bolanos, Peter J Hosein, Danylo F Cabral, Peter J Fried

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Thematic evolution and research trends in chemotherapy-induced peripheral neuropathy: a bibliometric and visual analysis from 1992 to 2024.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marlon L WongDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United States.
Lisa M McTeagueDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Gabriel GonzalezDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United States.
Juan P GonzalezDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United States.
Jessica L BolanosDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United States.
Peter J HoseinDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United States.
Danylo F CabralHarvard Medical School Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Boston, ML, United States.
Peter J FriedHarvard Medical School Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Boston, ML, United States.

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
NIAAA NIH HHS P50 AA010761
6 · The paper itself

Abstract

Introduction: This study aims to provide preliminary descriptive data on transcranial magnetic stimulation (TMS) measures obtained in Black and Hispanic/Latino individuals with chronic painful peripheral neuropathy (PN), including those with chemotherapy-induced peripheral neuropathy (CIPN) and diabetic neuropathy (DN). Both CIPN and DN share similar neuropathic symptoms and underlying physiological mechanisms, in particular altered central nervous system processing. TMS is a non-invasive technique that can assess corticospinal excitability and the function of GABAergic and glutamatergic pathways, potentially serving as a diagnostic or prognostic tool for PN. Methods: This study utilized data from a pilot randomized sham-controlled trial that tested the impact of patient education videos on the effect of transcutaneous auricular vagus nerve stimulation (taVNS) in Black and Hispanic/Latino individuals living with PN. TMS measures, including resting motor threshold (RMT), MEP amplitude following unconditioned single-pulse TMS (spTMS) and paired-pulse TMS measures of short interval intracortical inhibition (SICI), and intracortical facilitation (ICF), were assessed twice on separate visits. Test-retest reliability was evaluated, and changes in TMS measures following transcutaneous auricular vagus nerve stimulation were computed. Results: Pre-intervention TMS measures showed smaller-than-medium sized differences between CIPN and DN groups. The study found good test-retest reliability for TMS measures, with ICC values between 0.69 and 0.95 for all TMS measures of interest. Discussion: Overall, TMS measures demonstrated good reliability in this sample of Black and Hispanic/Latino individuals with PN, and these findings provide valuable preliminary data for future studies aimed at establishing the psychometric properties and diagnostic utility of TMS measures in PN.

Indexed as

chemotherapy induced peripheral neuropathydiabetic neuropathyhealth disparitiesperipheral neuropathytranscranial magnetic stimulation

Identifiers

PMID40529545
PMCPMC12171121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.