ReviewFrontiers in pharmacology2025
Molecular mechanisms of neuroprotective effect of rutin.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative phytochemical profiling and meta‑analysis of public transcriptomic datasets uncover species‑ and organ‑specific patterns of flavonoid and phenolic biosynthesis in Ferula species.BMC plant biology · 2026Pooled it
- Flavonoids as multi-target protective agents against aflatoxin B1 toxicity: mechanistic convergence and translational challenges.Poultry science · 2026Review
- Rutin as a multi-target anti-inflammatory phytochemical in arthritic disorders: pharmacological mechanisms and therapeutic potential.Inflammopharmacology · 2026Review
- Special Issue: "Potential Prevention and Treatment of Neurodegenerative Disorders".International journal of molecular sciences · 2026Article
- Rutin attenuates acrylamide-induced oxidative liver injury.Molecular biology reports · 2026Article
- Antipyretic and Antinociceptive Activities of Tri-Phol-That Extract and Its Flavonoids:ACS omega · 2026Article
- Natural products and neurocognitive disorders: Mechanistic insights and research advances (Review).Molecular medicine reports · 2026Review
- Article
- The Flavonoid Rutin Enhances Temozolomide Sensitivity in Glioblastoma Spheroids by Modulating Chemoresistance via PI3K/AKT, STAT3, Redox and Kynurenine Pathways, and Altering ECM Remodeling Associated with Reduced Migration.Antioxidants (Basel, Switzerland) · 2026Article
- Biologically Active Compounds and Antioxidant and DNA-Protective Potential of Rhodope AvensMolecules (Basel, Switzerland) · 2026Article
- Rutin as a Potential Therapeutic Agent for Multi-Organ Ischemia-Reperfusion Injury: From Multidimensional Mechanisms to Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Characterization and Biological Activity of Rutin Extracted fromBiotech (Basel (Switzerland)) · 2026Article
- Gold nanoparticles incorporating rutin hydrate for targeting oxidative stress-driven neurodegeneration.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- NLRP3 Inflammasome Activation in Oxidative Stress: A Key Mechanism Driving Neuroinflammation.Neuroimmunomodulation · 2026Review
- Review
- Phytochemical Constituent of Devil Weed (Molecules (Basel, Switzerland) · 2025Article
- Article
- Investigation of the inhibitory effects of total flavonoids of litchi seed onFrontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological diseases, including stroke, Alzheimer's disease, Parkinson's disease, and diabetic neuropathy, pose a significant global health burden. The rising incidence of these diseases, driven by factors including an aging population, lifestyle changes, and environmental influences, has intensified the urgent need for effective neuroprotective therapies. Rutin, a natural flavonoid glycoside widely distributed in various plants including buckwheat, citrus fruits, and onions, has garnered significant attention as a promising neuroprotective agent. This review comprehensively evaluates the current research on rutin's multifaceted neuroprotective mechanisms, which encompass antioxidant, anti-inflammatory, anti-apoptotic, antidepressant, anticonvulsant, and analgesic effects, as well as its role in enhancing neural signal transduction, improving learning and memory, and protecting the blood-brain barrier. However, despite its broad spectrum of neuroprotective effects and favorable safety profile, the clinical application of rutin is currently limited by its relatively low bioavailability. To address this limitation and fully harness rutin's therapeutic potential, future research should prioritize the development of innovative formulations designed to enhance its bioavailability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.