ArticleCytotechnology2025
Falcarindiol promotes beige adipocyte-related gene expression and mitochondrial respiration in human preadipocyte-derived adipocytes.
Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Identification of a novel oral potential multiple agonist for obesity treatment: multi-target in silico study.Journal of computer-aided molecular design · 2026Article
- Falcarindiol alleviates airway inflammation and oxidative stress in asthma through Nrf2 pathway activation.Scientific reports · 2026Article
- The context-dependent roles of PPAR-γ in adipocyte differentiation and obesity: a master regulator with dual functions.Frontiers in nutrition · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Falcarindiol, a typical polyacetylene compound found in Apiaceae vegetables, activates peroxisome proliferator-activated receptor γ (PPARγ). However, whether it induces the browning of adipocytes through PPARγ activation is unclear. In this study, we aimed to clarify the effects of falcarindiol on adipocyte browning and mitochondrial respiration in human preadipocyte-derived adipocytes. Human primary cultured cells were differentiated for 8 days in the presence of falcarindiol. The expression of PPARγ target and beige adipocyte-related genes was measured using quantitative real-time PCR, and the accumulation of lipid droplets and uncoupling protein 1 (UCP1) protein expression were evaluated using immunohistochemistry. The oxygen consumption rate was measured using a Seahorse flux analyzer. Falcarindiol increased the expression of PPARγ target genes, including
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Registered trials
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