ArticleGMS hygiene and infection control2025
Material compatibility of guanidine thiocyanate for decontamination of nickel-titanium root canal instruments after potential exposure to prions.
Article in GMS hygiene and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: Due to the effectiveness of guanidine thiocyanate (GdnSCN) for the decontamination of prion protein aggregates, which are the causative agent of transmissible spongiform encephalopathy, the influence on the bending stiffness and torsional strength of endodontic nickel-titanium files should be tested to provide a potential alternative to single-use if necessary. Method: For the investigation, nitrite-titanium-coated EasyShape Results: Compared to the untreated control (n=12), decontamination with GdnSCN has no effect on the torsional strength or flexural rigidity of the tested endodontic instruments of sizes 25.06 and 35.04 (n=18 each) when used properly. On the other hand, the exposure time of 12 h reduced the bending moment and torsion angle of instrument size 25.06, while the material properties of size 35.04 files are not affected. Discussion: Based on the results, the maximum 8-fold application of 6 M GdnSCN solution for 15 min for decontamination of endodontic nickel-titanium files can be considered. Although the sterilization process has no influence on the fracture behavior, it is important to clarify for clinical practice what influence the overall reprocessing process has on the performance of the instruments.
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