SynthesisFrontiers in neurology2025
Comparative efficacy of non-pharmacological interventions for Parkinson's disease with constipation: a systematic review and network meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
Background: This network meta-analysis aims to evaluate the comparative efficacy of non-pharmacological interventions on Parkinson's disease (PD) with constipation. Methods: A comprehensive search was conducted in seven major databases (CINAHL, the Cochrane Central Register of Controlled Trials [CENTRAL], Embase, PubMed, Web of Science, Chinese National Knowledge Infrastructure [CNKI], and Wanfang) up to August 2024. Eligible randomized controlled trials (RCTs) that evaluated non-pharmacological interventions for PD with constipation were included. Methodological quality was assessed using the Cochrane Risk of Bias tool, and a frequentist network meta-analysis (NMA) was performed using STATA 18 to estimate relative treatment effects. Results: From 2084 initially identified records, 12 RCTs ( Conclusion: Our findings suggest that non-pharmacological approaches, particularly PA-based interventions, may offer clinically meaningful benefits for constipation management in PD. Nevertheless, the relatively small number of available studies and methodological limitations in several trials necessitate cautious interpretation. Further rigorously designed RCTs are warranted to confirm these preliminary observations and establish optimal treatment protocols. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, CRD42024565248.
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