ArticleFrontiers in neurology2025
L-shaped relationship between dietary vitamin E intake and migraine in adults: a cross-sectional analysis of NHANES 1999-2004.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Several previous studies have suggested that micronutrients with antioxidant properties are protective factors against migraine. Despite being an important dietary antioxidant, the relationship between dietary vitamin E and migraine has not been extensively studied. This study sought to understand the association between dietary vitamin E intake and the incidence of migraine. Methods: Data from the National Health and Nutrition Examination Survey (1999-2004) were used in this cross-sectional analysis. To assess the association between dietary vitamin E intake and migraine, we employed logistic regression, restricted cubic spline regression, and stratified analyses. Results: This study included 10,063 participants who were 20 years old or older, 20.1% (2018/10,063) of whom reported suffering from migraine. Compared with the lowest vitamin E intake T1 (<4.5 mg/day), the adjusted odds ratios (ORs) of dietary vitamin E intake and migraine for T2 (4.5-7.8 mg/day) and T3 (>7.8 mg/day) were 0.85 (95% confidence interval [CI]: 0.74-0.98, Conclusion: In adults, the association between dietary vitamin E intake and migraine is an L-shaped curve (nonlinear,
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