ArticleFrontiers in nutrition2025
Associations of dietary inflammatory index and composite dietary antioxidant index with erectile dysfunction and the mediating role of metabolic dysregulation: a cross-sectional analysis of NHANES 2001-2004 data.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Inflammatory index-based nomogram for risk stratification of erectile dysfunction: a cross-sectional study with dual-cohort validation and mendelian randomization analysis.Translational andrology and urology · 2025Article
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8 authors.
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Abstract
Background: Inflammation and oxidative stress are a common and fundamental factor in the pathological process leading to erectile dysfunction (ED) and metabolic dysregulation. We aimed to reveal the relationship between the DII, composite dietary antioxidant index (CDAI), and ED, as well as the mediating role of MS, TyG index, MAP, UA, and TC on this relationship. Methods: This study included 1,488 participants from the NHANES surveys conducted between 2001 and 2004. The DII was constructed using 27 dietary components related to inflammatory potential, while the CDAI was built using six key minerals and vitamins. In the analysis, Spearman correlation, generalized linear models, and weighted logistic regression models were employed. The mediating roles of metabolic indicators in the relationships were investigated using Causal mediation analysis. Results: After comprehensive adjustment for confounding factors, we found a significant association between DII (OR: 1.07, 95% CI: 1.03-1.11, Conclusion: This study indicates that DII and CDAI were significantly associated with ED.
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