Evidence map›Paper›PMID 40529417›Full record

SynthesisFrontiers in nutrition2025

Lactobacillus GG and other probiotics in pediatric food allergy treatment: a network meta-analysis.

Li Xiaohua, Du Yiting, Li Qin, Zhai Yang, Wu Shumao, Peng Li, Pan Yi, Chen Lingmei, Liao Wenge, Li Maoxia

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Li Xiaohua *Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Du Yiting *Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Li QinChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Zhai YangChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wu ShumaoChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Peng LiChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Pan YiChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Chen LingmeiChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Liao WengeChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Li MaoxiaChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Food allergies are a significant health challenge in children, impacting quality of life and posing a burden on healthcare systems. Probiotics have been proposed as a potential treatment for food allergies, but their efficacy remains controversial. This systematic review and network meta-analysis aimed to assess the comparative effectiveness of different probiotics in managing pediatric food allergies. Methods: Following the Cochrane Handbook and PRISMA guidelines, a systematic search was conducted across PubMed, Cochrane Library, Web of Science, and Medline up to March 5, 2024. Randomized controlled trials (RCTs) evaluating probiotics for pediatric food allergies were included. The Cochrane risk of bias tool was used for quality assessment. Network meta-analyses were performed using random-effects models to calculate standardized mean differences (SMDs), odds ratios (ORs), and surface under the cumulative ranking curve (SUCRA) for different probiotics. Results: Sixteen RCTs involving 1,502 participants aged 1 month to 10 years were included. Eight probiotic interventions were analyzed. Lactobacillus GG (LGG) was identified as the most effective in reducing Scoring Atopic Dermatitis (SCORAD) scores (SMD = -4.24, 95% CI [-7.12, -1.36]; Conclusion: This study suggests that LGG is the most effective probiotic for improving clinical outcomes in pediatric food allergy management, particularly for SCORAD scores and quality of life. However, further high-quality RCTs are needed to validate these findings and explore the mechanisms underlying the differential efficacy of probiotic strains.

Indexed as

food allergyLactobacillus GGnetwork meta-analysispediatricprobioticsquality of lifeSCORAD

Identifiers

PMID40529417
PMCPMC12172551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.