Evidence map›Paper›PMID 40529343›Full record

ReviewBiochemistry and biophysics reports2025

Engineering bacterial cell morphology for the design of robust cell factories.

Maarten Lubbers, Nova Jaspers, Dennis Claessen

Abstract readReview
In one paragraph

Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maarten LubbersMicrobial Sciences, Institute of Biology, Leiden University, PO Box 9505, 2300 RA, Leiden, the Netherlands.
Nova JaspersMicrobial Sciences, Institute of Biology, Leiden University, PO Box 9505, 2300 RA, Leiden, the Netherlands.
Dennis ClaessenMicrobial Sciences, Institute of Biology, Leiden University, PO Box 9505, 2300 RA, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria come in a wide variety of shapes, ranging from spherical or rod-shaped unicellular cells to complex multicellular structures. These shapes have evolved to benefit the organism in its natural environment. However, industry often takes such organisms from their natural environment to produce useful molecules that favor mankind. Their natural morphology is often far from optimal for use in an industrial setting. Filamentous bacteria, for instance, have a morphology that presents unique challenges for industrial settings. Therefore, various engineering approaches have been developed to optimize their morphology. This review explores a spectrum of successful engineering strategies, offering insights and providing inspiration for future advancements. It holds the potential to lead the way in optimizing morphology in challenging microorganisms and thus improve their exploitability in biotechnology.

Indexed as

L-formsMorphology engineeringSynthetic biologyWall-deficient bacteria

Identifiers

PMID40529343
PMCPMC12173618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.