ArticleFrontiers in neuroscience2025
Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Discovery of aloe-emodin as an antidepressant agent by targeting RANBP9.Molecular diversity · 2026Article
- D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease.Cellular and molecular neurobiology · 2026Review
- Comparable Immune Alterations and Inflammatory Signatures in ME/CFS and Long COVID.Biomedicines · 2025Article
Corrections and comments
- Retracted
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), as one of the major ionic glutamate receptors, plays a dominant role in antidepressant effects, especially in synaptic plasticity. Few studies have been conducted on changes of NMDAR-related indicators and inflammatory cytokines in major depressive disorder (MDD) patient's peripheral blood before and after effective clinical perceptual recovery. This study aims to investigate changes in plasma biomarker levels related to NMDAR function in MDD patients receiving effective antidepressant treatment and their relationship with clinical outcomes. Methods: A total of 70 subjects of MDD having been discharged with an improvement rated a 50% or greater reduction by the Hamilton Depression Scale (HAMD-17) were hereby recruited. Changes in scores on the Symptom Checklist-90 (SCL-90), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), HAMD, and Hamilton Anxiety Scale (HAMA) were compared before and after therapy. Plasma D-serine (DSR), Glycine (Gly), Threonine (Thr), Glu, serine hydroxymethyltransferase (SHMT), interleukin (IL)-6, IL-8, IL-1β, IL-17, and tumor necrosis factor-alpha (TNF- Results: (i) Plasma glutamate levels in MDD patients had increased at discharge and decreased levels of IL-17, IL-1β, IL-6, TNF- Conclusion: Indicators related to NMDAR function, including Glu, IL-6, IL-8, IL-1β, IL-17, and TNF-
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