Evidence map›Paper›PMID 40529190›Full record

ArticleBioactive materials2025

Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats.

Qiujiang Li, Bowen Hu, Linan Wang, Lei Wang, Cong Feng, Zhuang Zhang, Zhipeng Deng, Yang Xiao, Bo Yuan, Xiangdong Zhu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiujiang LiDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Bowen HuDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Linan WangDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Lei WangDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Cong FengNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China.
Zhuang ZhangDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Zhipeng DengDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Yang XiaoDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Bo YuanNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China.
Xiangdong ZhuNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China.
Xiangfeng LiNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China.
Xi YangDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Yueming SongDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China.
Xingdong ZhangNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interbody fusion devices are critical in spinal surgery to restore spinal stability, reduce pain and improve function. Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological inertness limits bone regeneration and may lead to poor fusion. In this study, a novel strategy for preparing bioactive biomineralized PEEK cages was developed using a unique combination of osteoinductive CaP bioceramic fillings in the cage window, acid sulfonation and simulated body fluid incubation.

Indexed as

BiomineralizationGoatHydroxyapatitePolyetheretherketoneSpinal fusion

Identifiers

PMID40529190
PMCPMC12173203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.