ArticleFrontiers in bioengineering and biotechnology2025
Age-related differences in intramuscular fat distribution: spatial quantification in human ankle plantar flexors.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Indroduction: Accumulation of intramuscular fat (IMF) is an important marker of skeletal muscle health, typically reported as the mean intramuscular fat fraction (FF) from quantitative magnetic resonance imaging (MRI). However, such a summary measure does not reveal the spatial distribution of the FF through the muscle volume, and currently no methods to quantify intramuscular FF spatial distribution have been reported. This study assessed two- and three-dimensional characteristics of intramuscular FF spatial distribution and investigated age-related differences in intramuscular FF clustering in medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles. Methods: A total of 32 physically active young ( Results: Older adults exhibited significantly shorter Delaunay mean edge lengths compared to young (MG: 2.6 ± 0.5 mm vs. 3.2±0.4 mm, Discussion: This work provides an objective framework for characterizing intramuscular FF spatial distribution, providing a means to track skeletal muscle fatty replacement and provide more robust and sensitive markers of skeletal muscle health.
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