Evidence map›Paper›PMID 40529176›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors.

Pierre Springuel, Tiffany Hood, Fern Slingsby, Timo Schmidberger, Nicola Bevan, Noushin Dianat, Julia Hengst, Qasim A Rafiq

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierre SpringuelDepartment of Biochemical Engineering, University College London, London, United Kingdom.
Tiffany HoodDepartment of Biochemical Engineering, University College London, London, United Kingdom.
Fern SlingsbyProduct Excellence Bioreactor Technologies, Sartorius Stedim UK Limited, Epsom, United Kingdom.
Timo SchmidbergerSartorius Stedim Biotech GmbH, Goettingen, Germany.
Nicola BevanEssen BioScience Ltd. (part of the Sartorius Group), Royston, United Kingdom.
Noushin DianatSartorius Stedim FMT S.A.S., Aubagne, France.
Julia HengstSartorius Stedim Biotech GmbH, Goettingen, Germany.
Qasim A RafiqDepartment of Biochemical Engineering, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

adaptiveCAR-T cellperfusionprocess intensificationstirred-tank bioreactorxeno-and serum-free medium

Identifiers

PMID40529176
PMCPMC12171161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.