ArticleFrontiers in medicine2025
Efficacy and safety of tranexamic acid in reducing hidden blood loss during unilateral total knee arthroplasty: a retrospective study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07174895 (Efficacy of Tranexamic Acid With/Without Drain in Knee Arthroplasty), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Tranexamic Acid With/Without Drain in Knee Arthroplasty: A Study From Northwest Syria
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk prediction models for blood transfusion in patients undergoing total hip and knee arthroplasty: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- The efficacy of local tranexamic acid injection in reducing intraoperative bleeding and improving surgical field quality in septoplasty: a randomized controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Efficacy of tranexamic acid with/without drain in knee arthroplasty: a randomized prospective clinical study from Northwest Syria.Annals of medicine and surgery (2012) · 2026Article
- Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Analysis of independent risk factors for high hidden blood loss following total knee arthroplasty.PloS one · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective study evaluates the efficacy and safety of tranexamic acid (TXA) in reducing hidden blood loss during unilateral total knee arthroplasty (TKA) in patients with osteoarthritis. As the aging population leads to a rise in degenerative knee joint diseases, TKA has become a common surgical intervention. However, it is often associated with significant hidden blood loss, accounting for 60-75% of total blood loss, which can result in complications such as anemia and increased transfusion needs. Our study included 123 patients who underwent TKA between June 2019 and June 2022, divided into an observation group receiving TXA and a control group receiving saline. TXA was administered intravenously before surgery and locally into the joint cavity post-incision. The study found that TXA significantly reduced total blood loss by 37.4%, with a notable decrease in hidden blood loss (
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Registered trials
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