Diagnostic value of the combined detection of serum tumor necrosis factor-α and fecal calprotectin in early sepsis-related encephalopathy.

Chenghong OuYang, ChunLi Yang, Qi Wu, Fang Liu, Zhenhuan Chen

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Chenghong OuYang *Department of Critical Care Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

ChunLi Yang *Department of Critical Care Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Qi WuDepartment of Critical Care Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Fang LiuDepartment of Critical Care Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Zhenhuan ChenDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Funding

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6 · The paper itself

Abstract

Objective: To investigate the value of tumor necrosis factor-α (TNF-α) and fecal calprotectin in the early diagnosis and prognosis of sepsis-associated encephalopathy (SAE). Methods: We recruited 150 patients with sepsis, admitted from January 2020 to January 2022. Of these, 80 patients had SAE and 70 patients did not. The levels of serum TNF- Results: The APACHE II and SOFA scores and 28-day mortality of the SAE group were significantly higher than those of the sepsis group, which indicated that the condition of the SAE group was more critical. In the SAE group, TNF-α and fecal calprotectin levels were positively correlated with the APACHE II and SOFA scores ( Conclusions: TNF-α and fecal calprotectin may be involved in the pathogenesis of SAE. Both have high specificity and sensitivity for early SAE diagnosis. Moreover, they have good predictive value and can serve as prognostic indicators.

Indexed as

diagnostic valueearly sepsis-related encephalopathyfecal calprotectinpathogenesis of SAEserum tumor necrosis factor-α

Identifiers

PMID40529149

DOI10.3389/fmed.2025.1598624

PMCPMC12171133

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